Article
Microevolution of Pseudomonas aeruginosa in the airways of people with cystic fibrosis.
Current opinion in immunology - 1 Aug 2023
Cramer Nina, Klockgether Jens, Tümmler Burkhard
Abstract excerpt
The chronic infections of cystic fibrosis (CF) airways with Pseudomonas aeruginosa are a paradigm of how environmental bacteria can conquer, adapt, and persist in an atypical habitat and successfully evade defense mechanisms and chemotherapy in a susceptible host. The within-host evolution of intraclonal diversity has been examined by whole-genome sequencing, phenotyping, and competitive fitness experiments of...
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