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Article

Stage‐Specific Adaptation of Hypermutable<i>Pseudomonas aeruginosa</i>Isolates during Chronic Pulmonary Infection in Patients with Cystic Fibrosis

1 Dec 2006

Abstract excerpt

BACKGROUND: Pseudomonas aeruginosa (PA) strains with defective DNA mismatch repair genes generate numerous bacterial variants because of high mutation rates. In cystic fibrosis (CF), such mutator strains may lead to the rapid selection of survivors that are specifically adapted to the hostile environment of the inflamed CF lung. METHODS: Genotypes and phenotypes of 111 PA variants descending from 3 distinct...

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PMID: 17152010
DOI: 10.1086/509821

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