Human cytomegalovirus (HCMV) glycoprotein M occurs in three distinct genotypes in laboratory strains and clinical isolates.

doi:10.1016/j.jcv.2025.105799

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Article

Human cytomegalovirus (HCMV) glycoprotein M occurs in three distinct genotypes in laboratory strains and clinical isolates.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Jun 2025

Al-Alfard Alia, Buhamad Zahrah, Duffey Julia, Lovell Simon, Klapper Paul, Vallely Pamela

Abstract excerpt

BACKGROUND: HCMV carries virus-encoded envelope glycoproteins important for viral attachment, entry into host cells and replication. These glycoproteins have polymorphic features resulting in distinct genotypes some of which have been associated with disease outcome. Glycoprotein complex II comprises glycoproteins M (gM) and N (gN) and is essential for viral replication. Glycoprotein N is highly polymorphic while...

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Topics

Humans
Cytomegalovirus
Genotype
Phylogeny
Cytomegalovirus Infections
Viral Envelope Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Molecular Sequence Data

Viral Matrix Proteins

Amino Acid Sequence

Sequence Analysis, DNA

Polymerase Chain Reaction

Polymorphism, Genetic

Hydrophobic and Hydrophilic Interactions

DNA, Viral

Source

Open in PubMed

Identifiers

PMID: 40288158
DOI: 10.1016/j.jcv.2025.105799

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