Article
SNEP: Simultaneous detection of nucleotide and expression polymorphisms using Affymetrix GeneChip.
BMC bioinformatics - 6 May 2009
Fujisawa Hironori, Horiuchi Youko, Harushima Yoshiaki, Takada Toyoyuki, Eguchi Shinto, Mochizuki Takako, Sakaguchi Takayuki, Shiroishi Toshihiko, Kurata Nori
Abstract excerpt
BACKGROUND: High-density short oligonucleotide microarrays are useful tools for studying biodiversity, because they can be used to investigate both nucleotide and expression polymorphisms. However, when different strains (or species) produce different signal intensities after mRNA hybridization, it is not easy to determine whether the signal intensities were affected by nucleotide or expression polymorphisms. To...
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