Article
MTHFR 677TT alone and IRF6 820GG together with MTHFR 677CT, but not MTHFR A1298C, are risks for nonsyndromic cleft lip with or without cleft palate in an Indian population.
Genetic testing and molecular biomarkers - 1 Jun 2009
Ali Akhtar, Singh Subodh Kumar, Raman Rajiva
Abstract excerpt
AIM: To determine the association of three SNPs, IRF6 G820A, MTHFR C677T, and MTHFR A1298C, with nonsyndromic cleft lip with or without cleft palate (NSCL/P) in an Indian population. METHOD: A total of 323 NSCL/P patients, 116 of their mothers, 108 of their fathers, and 214 normal controls have been examined for the above three SNPs. RESULT: Frequency of IRF6 GG was 65% in controls, 78% in cases, 84% in...
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