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Article

Decline in daily running distance presages disease onset in a mouse model of ALS.

Neuromolecular medicine - 1 Jan 2009

Bruestle Daniel A, Cutler Roy G, Telljohann Richard S, Mattson Mark P

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is characterized by progressive degeneration of lower motor neurons resulting in paralysis and death. Epidemiological and clinical findings suggest that a decline in athletic performance may presage the clinical onset of ALS, but this possibility has not been tested in an animal model. By placing running wheels in each mouse's cage to measure their exercise activity, we show...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19418268
DOI: 10.1007/s12017-009-8064-3
PMCID: PMC2706299

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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