Article
Gene mutations in esophageal mucosa of chagas disease patients.
Anticancer research - 1 Apr 2009
DA Silva Manoel-Caetano Fernanda, Silveira Aparecida F P, Silva Ana Elizabete
Abstract excerpt
BACKGROUND: Chagas disease patients with longstanding megaesophagus have a significantly increased risk for esophageal carcinoma. MATERIALS AND METHODS: PCR-SSCP analysis and DNA sequencing of esophageal mucosa from Chagas disease patients (with or without megaesophagus) in the exons of the TP53, CDKN2A and FHIT genes were performed. RESULTS: SSCP analysis showed a mobility shift in 2/20 patients with grade IV...
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