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Article

TNFalpha promotes osteogenic differentiation of human mesenchymal stem cells by triggering the NF-kappaB signaling pathway.

Bone - 1 Aug 2009

Hess Katrin, Ushmorov Alexey, Fiedler Jörg, Brenner Rolf E, Wirth Thomas

Abstract excerpt

Mesenchymal stem cells are multipotent cells able to differentiate into different mesenchymal lineages. Studies in the past had suggested that two of these mesenchymal differentiation directions, the chondrogenic and the myogenic differentiation, are negatively regulated by the transcription factor NF-kappaB. Although osteogenic differentiation has been extensively studied, the influence of NF-kappaB on this...

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Source

Identifiers

PMID: 19414075
DOI: 10.1016/j.bone.2009.04.252

Genes

TNF
RUNX2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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