Article
Refinement and reduction through the control of variation.
Alternatives to laboratory animals : ATLA - 1 Jun 2004
Festing Michael F W
Abstract excerpt
The key to doing animal experiments efficiently, while using the minimum number of animals without loss of scientific information, lies in good control of random variation, and recognition and control of "fixed effect" variation, such as the sex or strain of the animals. However, many scientists erroneously assume that the use of outbred, genetically heterogeneous animals is justified, because in some way, they...
Topics
- Animals
- Animals, Laboratory
- Female
- Genetic Variation
- Male
- Sample Size