Article
Global transcriptional characterization of a mouse pulmonary epithelial cell line for use in genetic toxicology.
Toxicology in vitro : an international journal published in association with BIBRA - 1 Aug 2009
Berndt-Weis M Lynn, Kauri Lisa M, Williams Andrew, White Paul, Douglas George, Yauk Carole
Abstract excerpt
Prior to its application for in vitro toxicological assays, thorough characterization of a cell line is essential. The present study uses global transcriptional profiling to characterize a lung epithelial cell line (FE1) derived from MutaMouse [White, P.A., Douglas, G.R., Gingerich, J., Parfett, C., Shwed, P., Seligy, V., Soper, L., Berndt, L., Bayley, J., Wagner, S., Pound, K., Blakey, D., 2003. Development and...
Topics
- Animals
- Benzo(a)pyrene
- Cell Line
- Enzyme Induction
- Epithelial Cells
- Gene Expression Profiling
- Gene Expression Regulation
- Lung
- Male
- Mice
- Mice, Transgenic
- Mutagenesis
- Mutagens
- Oligonucleotide Array Sequence Analysis