Article
RNA (E6 and E7) assays versus DNA (E6 and E7) assays for risk evaluation for women infected with human papillomavirus.
Journal of clinical microbiology - 1 Jul 2009
Cattani Paola, Siddu Alessia, D'Onghia Sara, Marchetti Simona, Santangelo Rosaria, Vellone Valerio G, Zannoni Gian Franco, Fadda Giovanni
Abstract excerpt
In the majority of cases, high-risk human papillomavirus (HR HPV) infections regress spontaneously, with only a small percentage progressing to high-grade lesions. Current screening methods are based on DNA detection. An alternative would be to monitor expression of the E6 and E7 viral oncogenes continuously expressed by malignant phenotypes. In the work reported in this paper, we compared the two methods for a...
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