Article
Comparison of oncogenic HPV type-specific viral DNA load and E6/E7 mRNA detection in cervical samples: results from a multicenter study.
Journal of medical virology - 1 Mar 2013
Broccolo Francesco, Fusetti Lisa, Rosini Sandra, Caraceni Donatella, Zappacosta Roberta, Ciccocioppo Lucia, Matteoli Barbara, Halfon Philippe, Malnati Mauro S, Ceccherini-Nelli Luca
Abstract excerpt
High-risk human papillomavirus (HR-HPV) genotype viral load and E6/E7 mRNA detection are proposed as surrogate markers of malignant cervical lesion progression. Currently, the use of commercially available DNA-based or mRNA-based tests is under investigation. In this study, the viral DNA load and E6/E7 mRNA detection of the five most common HR-HPV types detected in cervical cancer worldwide were compared in 308...
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