Comparison of oncogenic HPV type-specific viral DNA load and E6/E7 mRNA detection in cervical samples: results from a multicenter study.

doi:10.1002/jmv.23487

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Article

Comparison of oncogenic HPV type-specific viral DNA load and E6/E7 mRNA detection in cervical samples: results from a multicenter study.

Journal of medical virology - 1 Mar 2013

Broccolo Francesco, Fusetti Lisa, Rosini Sandra, Caraceni Donatella, Zappacosta Roberta, Ciccocioppo Lucia, Matteoli Barbara, Halfon Philippe, Malnati Mauro S, Ceccherini-Nelli Luca

Abstract excerpt

High-risk human papillomavirus (HR-HPV) genotype viral load and E6/E7 mRNA detection are proposed as surrogate markers of malignant cervical lesion progression. Currently, the use of commercially available DNA-based or mRNA-based tests is under investigation. In this study, the viral DNA load and E6/E7 mRNA detection of the five most common HR-HPV types detected in cervical cancer worldwide were compared in 308...

Topics

Adult
Aged
DNA, Viral
Female
Genotype
Humans
Middle Aged
Molecular Diagnostic Techniques
Papillomaviridae
Papillomavirus Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Predictive Value of Tests

RNA, Messenger

RNA, Viral

Real-Time Polymerase Chain Reaction

Retrospective Studies

Sensitivity and Specificity

Sequence Analysis, DNA

Uterine Cervical Neoplasms

Source

Open in PubMed

Identifiers

PMID: 23280876
DOI: 10.1002/jmv.23487

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-23280876-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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