A comparison of human papillomavirus genotype-specific DNA and E6/E7 mRNA detection to identify anal precancer among HIV-infected men who have sex with men.

doi:10.1158/1055-9965.EPI-12-0984

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Article

A comparison of human papillomavirus genotype-specific DNA and E6/E7 mRNA detection to identify anal precancer among HIV-infected men who have sex with men.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2013

Castle Philip E, Follansbee Stephen, Borgonovo Sylvia, Tokugawa Diane, Schwartz Lauren M, Lorey Thomas S, LaMere Brandon, Gage Julia C, Fetterman Barbara, Darragh Teresa M, Rodriguez Ana Cecilia, Wentzensen Nicolas

Abstract excerpt

BACKGROUND: Human papillomavirus (HPV) RNA detection is reportedly more specific for the detection of anogenital precancer than HPV DNA but it is unknown whether this is due to detection of RNA or due to HPV genotype restriction. METHODS: A total of 363 human immunodeficiency virus (HIV)-positive men who have sex with men had two anal cytology samples taken and were evaluated using high-resolution anoscopy and...

Topics

Adult
Age Distribution
Anus Neoplasms
Biomarkers, Tumor
Cross-Sectional Studies
DNA, Viral
Genotype
HIV Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Homosexuality, Male

Human papillomavirus 16

Humans

Male

Middle Aged

Papillomavirus Infections

Precancerous Conditions

Prevalence

Prognosis

RNA, Messenger

Source

Open in PubMed Open full text

Identifiers

PMID: 23155136
DOI: 10.1158/1055-9965.EPI-12-0984
PMCID: PMC3538931

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-23155136-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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