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Article

Poor ovarian response to gonadotrophin stimulation is associated with FSH receptor polymorphism.

Reproductive biomedicine online - 1 Apr 2009

Achrekar Swati K, Modi Deepak N, Desai Sadhana K, Mangoli Vijay S, Mangoli Ranjana V, Mahale Smita D

Abstract excerpt

Similarities in the phenotype observed in women with FSH receptor mutation and in FSH receptor knockout mice have clearly established a critical role of this protein in normal gonadal function. Two common single nucleotide polymorphisms in the exonic region of the FSH receptor gene have been shown to be associated with altered ovarian response in subjects undergoing gonadotrophin treatment. Recent in-vitro...

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PMID: 19400992
DOI: 10.1016/s1472-6483(10)60127-7

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