Article
Polymorphisms in gonadotropin and gonadotropin receptor genes as markers of ovarian reserve and response in in vitro fertilization.
Fertility and sterility - 15 Mar 2013
La Marca Antonio, Sighinolfi Giovanna, Argento Cindy, Grisendi Valentina, Casarini Livio, Volpe Annibale, Simoni Manuela
Abstract excerpt
Since gonadotropins are the fundamental hormones that control ovarian activity, genetic polymorphisms may alter gonadal responsiveness to glycoproteins; hence they are important regulators of hormone activity at the target level. The establishment of the pool of primordial follicles takes place during fetal life and is mainly under genetic control. Consequently, single nucleotide polymorphisms (SNPs) in...
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