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Article

The nsP3 macro domain is important for Sindbis virus replication in neurons and neurovirulence in mice.

Virology - 5 Jun 2009

Park Eunhye, Griffin Diane E

Abstract excerpt

Sindbis virus (SINV), the prototype alphavirus, contains a macro domain in the highly conserved N-terminal region of nonstructural protein 3 (nsP3). However, the biological role of the macro domain is unclear. Mutations of amino acids 10 and 24 from asparagine to alanine in the ADP-ribose binding region of the macro domain impaired SINV replication and viral RNA synthesis particularly in neurons, but did not...

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Source

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Identifiers

PMID: 19395054
DOI: 10.1016/j.virol.2009.03.031
PMCID: PMC2683903

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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