Article
The secreted Helicobacter cysteine-rich protein A causes adherence of human monocytes and differentiation into a macrophage-like phenotype.
FEBS letters - 19 May 2009
Dumrese Claudia, Slomianka Lutz, Ziegler Urs, Choi Sung Sook, Kalia Awdhesh, Fulurija Alma, Lu Wei, Berg Douglas E, Benghezal Mohammed, Marshall Barry, Mittl Peer R E
Abstract excerpt
Helicobacter pylori genomes typically contain 8 or 9 genes that code for secreted and highly disulfide-bridged proteins designated Helicobacter cysteine-rich proteins (Hcp). Here we show that HcpA (hp0211) but not HcpC (hp1098) triggers the differentiation of human myeloid Thp1 monocytes into macrophages. Small amounts of HcpA cause the transition of round-shaped monocytes into cells with star-like morphologies,...
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