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Placental biomarkers of phthalate effects on mRNA transcription: application in epidemiologic research

23 Apr 2009

Abstract excerpt

BACKGROUND: CYP19 and PPARgamma are two genes expressed in the placental trophoblast that are important to placental function and are disrupted by phthalate exposure in other cell types. Measurement of the mRNA of these two genes in human placental tissue by quantitative real-time polymerase chain reaction (qPCR) offers a source of potential biomarkers for use in epidemiologic research. We report on methodologic...

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PMID: 19389254
DOI: 10.1186/1476-069x-8-20

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