Increased cell death in rat blastocysts exposed to maternal diabetes in utero and to high glucose or tumor necrosis factor-α in vitro

Abstract excerpt

The morphogenetic function of the transient phase of cell death that occurs during blastocyst maturation is not known but it is thought that its regulation results from a delicate balance between survival and lethal signals in the uterine milieu. In this paper, we show that blastocysts from diabetic rats have a higher incidence of dead cells than control embryos. Differential lineage staining indicated that...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bone Metabolism and Diseases
• Share to Clusterin in disease pathology
• Share to TGF-β signaling in diseases