Article
ADHD and DAT1: further evidence of paternal over-transmission of risk alleles and haplotype.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jan 2010
Hawi Z, Kent L, Hill M, Anney R J L, Brookes K J, Barry E, Franke B, Banaschewski T, Buitelaar J, Ebstein R, Miranda A, Oades R D, Roeyers H, Rothenberger A, Sergeant J, Sonuga-Barke E, Steinhausen H-C, Faraone S V, Asherson P, Gill M
Abstract excerpt
We [Hawi et al. (2005); Am J Hum Genet 77:958-965] reported paternal over-transmission of risk alleles in some ADHD-associated genes. This was particularly clear in the case of the DAT1 3'-UTR VNTR. In the current investigation, we analyzed three new sample comprising of 1,248 ADHD nuclear families to examine the allelic over-transmission of DAT1 in ADHD. The IMAGE sample, the largest of the three-replication...
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