Article
Methylation patterns within 5'-UTR of DAT1 gene as a function of allelic 3'-UTR variants and their maternal or paternal origin: May these affect the psychopathological phenotypes in children? An explorative study.
Neuroscience letters - 20 Nov 2022
Carpentieri Valentina, Pascale Esterina, Cerniglia Luca, Pucci Mariangela, D'Addario Claudio, Laviola Giovanni, Adriani Walter, Cimino Silvia
Abstract excerpt
Psychopathological symptoms such as depression/anxiety vs attention or aggression problems, in children, have been associated to altered expression of the DAT1/SLC6A3 gene. Inheriting specific 9- or 10-repeat VNTR alleles could modify the pattern of methylation in the CpGs islands at the 5'-UTR of the DAT1 gene. Through accurate recruitment at primary schools, we ended up with four subgroups of children: 9/9 and...
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