Article
A common haplotype at the dopamine transporter gene 5' region is associated with attention-deficit/hyperactivity disorder.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Dec 2008
Genro Júlia P, Polanczyk Guilherme V, Zeni Cristian, Oliveira Angélica S, Roman Tatiana, Rohde Luis A, Hutz Mara H
Abstract excerpt
The dopamine transporter (DAT) is the major site of methylphenidate action, which is one of the main drugs used to treat attention-deficit/hyperactivity disorder (ADHD). Most association studies with ADHD focused in a VNTR at the 3'-untranslated region of the gene (3'UTR) presenting conflicting results. However, the most common explanation to inconsistent results is variable linkage disequilibrium with an...
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