Article
Genetic association of insulin-like growth factor-1 polymorphisms with high-grade myopia in an international family cohort.
Investigative ophthalmology & visual science - 1 Sept 2010
Metlapally Ravikanth, Ki Chang-Seok, Li Yi-Ju, Tran-Viet Khanh-Nhat, Abbott Diana, Malecaze Francois, Calvas Patrick, Mackey David A, Rosenberg Thomas, Paget Sandrine, Guggenheim Jeremy A, Young Terri L
Abstract excerpt
PURPOSE: Evidence from human myopia genetic mapping studies (MYP3 locus), modulated animal models, and observations of glycemic control in humans suggests that insulin-like growth factor (IGF)-1 plays a role in the control of eye growth. This study was conducted to determine whether IGF-1 polymorphisms are associated with myopia in a large, international dataset of Caucasian high-grade myopia pedigrees. METHODS:...
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