Article
Mitochondrial DNA haplogroup T is associated with coronary artery disease and diabetic retinopathy: a case control study.
BMC medical genetics - 21 Apr 2009
Kofler Barbara, Mueller Edith E, Eder Waltraud, Stanger Olaf, Maier Richard, Weger Martin, Haas Anton, Winker Robert, Schmut Otto, Paulweber Bernhard, Iglseder Bernhard, Renner Wilfried, Wiesbauer Martina, Aigner Irene, Santic Danijela, Zimmermann Franz A, Mayr Johannes A, Sperl Wolfgang
Abstract excerpt
BACKGROUND: There is strong and consistent evidence that oxidative stress is crucially involved in the development of atherosclerotic vascular disease. Overproduction of reactive oxygen species (ROS) in mitochondria is an unifying mechanism that underlies micro- and macrovascular atherosclerotic disease. Given the central role of mitochondria in energy and ROS production, mitochondrial DNA (mtDNA) is an obvious...
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