Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ace-1 duplication in Anopheles gambiae: a challenge for malaria control.

Malaria journal - 18 Apr 2009

Djogbénou Luc, Labbé Pierrick, Chandre Fabrice, Pasteur Nicole, Weill Mylène

Abstract excerpt

BACKGROUND: Insecticide resistance is a rapid and recent evolutionary phenomenon with serious economic and public health implications. In the mosquito Anopheles gambiae s.s., main vector of malaria, resistance to organophosphates and carbamates is mainly due to a single amino-acid substitution in acetylcholinesterase 1 (AChE1). This mutation entails a large fitness cost. However, a resistant duplicated allele of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylcholinesterase
Share to Amino Acid Substitution
Share to Anopheles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Duplication

Share to Insect Vectors

Share to Insecticide Resistance

Share to Insecticides

Share to Mosquito Control

Source

Open in PubMed Open full text

Identifiers

PMID: 19374767
DOI: 10.1186/1475-2875-8-70
PMCID: PMC2679766

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ace-1 duplication in Anopheles gambiae: a challenge for malaria control.PMID 19374767Read ↗

An ace-1 gene duplication resorbs the fitness cost associated with resistance in Anopheles gambiae, the main malaria mosquitoSemantic proximity Read ↗

Despite structural identity, ace-1 heterogenous duplication resistance alleles are quite diverse in Anopheles mosquitoes.Semantic proximity Read ↗

High incidence of ace-1 duplicated haplotypes in resistant Culex pipiens mosquitoes from Algeria.Semantic proximity Read ↗

Identification and geographic distribution of the ACE-1R mutation in the malaria vector Anopheles gambiae in south-western Burkina Faso, West Africa.Semantic proximity Read ↗

Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locusSemantic proximity Read ↗

Genomic insights into the spread and evolution of insecticide resistance variants in Anopheles gambiae s.l. from Burkina Faso.Semantic proximity Read ↗

Estimation of allele-specific Ace-1 duplication in insecticide-resistant Anopheles mosquitoes from West AfricaSemantic proximity Read ↗

Independent duplications of the acetylcholinesterase gene conferring insecticide resistance in the mosquito Culex pipiens.Semantic proximity Read ↗

Evolutionary trade-offs associated with copy number variations in resistance alleles in Culex pipiens mosquitoes.Semantic proximity Read ↗

Resistance to pirimiphos-methyl in West African <i>Anopheles</i> is spreading via duplication and introgression of the <i>Ace1</i> locusSemantic proximity Read ↗

Evidence of introgression of the ace-1(R) mutation and of the ace-1 duplication in West African Anopheles gambiae s. s.Semantic proximity Read ↗

The evolutionary fate of heterogeneous gene duplications: A precarious overdominant equilibrium between environment, sublethality and complementation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.