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Article

Despite structural identity, ace-1 heterogenous duplication resistance alleles are quite diverse in Anopheles mosquitoes.

Heredity - 1 Apr 2024

Claret Jean-Loup, Di-Liegro Marion, Namias Alice, Assogba Benoit, Makoundou Patrick, Koffi Alphonsine, Pennetier Cédric, Weill Mylène, Milesi Pascal, Labbé Pierrick

Abstract excerpt

Anopheles gambiae s.l. has been the target of intense insecticide treatment since the mid-20th century to try and control malaria. A substitution in the ace-1 locus has been rapidly selected for, allowing resistance to organophosphate and carbamate insecticides. Since then, two types of duplication of the ace-1 locus have been found in An. gambiae s.l. populations: homogeneous duplications that are composed of...

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Identifiers

PMID: 38280976
DOI: 10.1038/s41437-024-00670-9
PMCID: PMC10997782

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