Article
Association between the CYP2D6*4 polymorphism and depression or anxiety in the elderly.
Pharmacogenomics - 1 Apr 2009
Bijl Monique J, Luijendijk Hendrika J, van den Berg Julia F, Visser Loes E, van Schaik Ron H N, Hofman Albert, Vulto Arnold G, van Gelder Teun, Tiemeier Henning, Stricker Bruno H Ch
Abstract excerpt
INTRODUCTION: 5-methoxytryptamine (5-MT), a precursor of serotonin, is considered to be an endogenous substrate of cytochrome P450 2D6 (CYP2D6). Homozygous carriers of the variant allele CYP2D6*4 lack CYP2D6 enzyme activity. Relative to extensive metabolizers, these poor metabolizers may have lower baseline serotonin concentrations in various brain regions, and may be more prone to depression or anxiety. AIM: To...
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