Article
Investigation of the role of polymorphisms at the alcohol and aldehyde dehydrogenase loci in genetic predisposition to alcohol-related end-organ damage.
Hepatology (Baltimore, Md.) - 1 Nov 1991
Day C P, Bashir R, James O F, Bassendine M F, Crabb D W, Thomasson H R, Li T K, Edenberg H J
Abstract excerpt
Little is known about factors determining individual susceptibility to the physical complications of alcohol abuse but genetically determined differences in ethanol metabolism may be important. The oxidative metabolism of alcohol is catalyzed by alcohol and aldehyde dehydrogenase. Polymorphisms h...
Topics
- Alcohol Dehydrogenase
- Alcoholism
- Aldehyde Dehydrogenase
- Alleles
- Chromosome Mapping
- Chronic Disease
- Gene Frequency
- Genetic Predisposition to Disease
- Humans
- Liver Cirrhosis, Alcoholic
- Pancreatitis
- Polymorphism, Genetic