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Article

Down-regulation of a manganese transporter in the face of metal toxicity.

Molecular biology of the cell - 1 Jun 2009

Jensen Laran T, Carroll Mark C, Hall Matthew D, Harvey Christopher J, Beese Sara E, Culotta Valeria C

Abstract excerpt

The yeast Smf1p Nramp manganese transporter is posttranslationally regulated by environmental manganese. Smf1p is stabilized at the cell surface with manganese starvation, but is largely degraded in the vacuole with physiological manganese through a mechanism involving the Rsp5p adaptor complex Bsd2p/Tre1p/Tre2p. We now describe an additional level of Smf1p regulation that occurs with toxicity from manganese, but...

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Identifiers

PMID: 19369420
DOI: 10.1091/mbc.e08-10-1084
PMCID: PMC2695789

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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