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Article

Regulation of the Drosophila engrailed gene by Polycomb repressor complex 2.

Mechanisms of development - 1 Jan 2000

Chen Sa, Rasmuson-Lestander Asa

Abstract excerpt

Suppressor-of-zeste-12 (Su(z)12) is a core component of the Polycomb repressive complex 2 (PRC2), which has a methyltransferase activity directed towards lysine residues of histone 3. Mutations in Polycomb group (PcG) genes cause de-repression of homeotic genes and subsequent homeotic transformations. Another target for Polycomb silencing is the engrailed gene, which encodes a key regulator of segmentation in the...

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Identifiers

PMID: 19368801
DOI: 10.1016/j.mod.2009.01.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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