Epidemiology and immunogenetic background of islet cell antibody--positive nondiabetic schoolchildren. Ulm-Frankfurt population study.

doi:10.2337/diab.40.11.1435

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Article

Epidemiology and immunogenetic background of islet cell antibody--positive nondiabetic schoolchildren. Ulm-Frankfurt population study.

Diabetes - 1 Nov 1991

Boehm B O, Manfras B, Seissler J, Schöffling K, Glück M, Holzberger G, Seidl S, Kühnl P, Trucco M, Scherbaum W A

Abstract excerpt

Islet cell antibodies (ICAs) were determined in a large cohort of white nondiabetic schoolchildren (n = 4287) from a homogenous population in southern Germany. The prevalence of ICA levels greater than or equal to 5 Juvenile Diabetes Foundation (JDF) U was 1.05% (95% confidence interval 0.8-1.4%). Analysis of HLA-DR beta and -DQ beta alleles revealed that the specificities found to be increased in...

Topics

Adolescent
Adult
Amino Acids
Autoantibodies
Child
Cross-Sectional Studies
DNA
Diabetes Mellitus, Type 1
Female
Germany
HLA-DQ Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HLA-DQ beta-Chains

HLA-DR Antigens

Humans

Male

Phenotype

Prevalence

Risk Factors

Source

Open in PubMed

Identifiers

PMID: 1936604
DOI: 10.2337/diab.40.11.1435

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1936604-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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