On testing for genetic association in case-control studies when population allele frequencies are known.

Abstract excerpt

With the emergence of Biobanks alongside large-scale genome-wide association studies (GWAS) we will soon be in the enviable situation of obtaining precise estimates of population allele frequencies for SNPs which make up the panels in standard genotyping arrays, such as those produced from Illumina and Affymetrix. For disease association studies it is well known that for rare diseases with known population minor...

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