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Article

Risk and Association of Specific HLA Alleles With Nintedanib-Induced Gastrointestinal Adverse Reactions: A Discovery Study in an Italian Population.

Clinical and translational science - 1 Oct 2025

Mocci Stefano, Littera Roberto, Deidda Silvia, Perra Andrea, Floris Matteo, Giglio Sabrina

Abstract excerpt

Idiopathic Pulmonary Fibrosis (IPF) is a progressive and fatal lung disease with limited treatment options. Nintedanib and pirfenidone are the only antifibrotic drugs approved by both the USA and European medicinal agencies, but their efficacy and tolerability remain concerns. This exploratory study investigates the association between genetic variation in the Major Histocompatibility Complex (MHC) region and...

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Identifiers

PMID: 41017748
DOI: 10.1111/cts.70371
PMCID: PMC12477543

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