Article
Tendon xanthomas in familial hypercholesterolemia are associated with cardiovascular risk independently of the low-density lipoprotein receptor gene mutation.
Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2005
Civeira Fernando, Castillo Sergio, Alonso Rodrigo, Meriño-Ibarra Erardo, Cenarro Ana, Artied Marta, Martín-Fuentes Paula, Ros Emilio, Pocoví Miguel, Mata Pedro
Abstract excerpt
OBJECTIVE: To investigate the significance of tendon xanthomas (TX) in heterozygous subjects with familial hypercholesterolemia (hFH). METHODS AND RESULTS: 951 men and women with genetic diagnosis of hFH were studied, of whom 278 (29.2%) presented TX. TX frequency increased with age from 6.9% in subjects 20 to 30 years to 38.3% at 51 to 60 years, with a decrease in those older than 60 years. Total and low-density...
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