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Article

Downregulation of Ches1 and other novel genes in oral cancer cells chronically exposed to areca nut extract.

Head & neck - 1 Feb 2011

Chen Yin-Ju, Liao Chun-Ta, Chen Po-Jen, Lee Li-Yu, Li Yi-Chen, Chen I-How, Wang Hung-Ming, Chang Joseph T, Chen Li-Ju, Yen Tzu-Chen, Tang Chuan-Yi, Cheng Ann-Joy

Abstract excerpt

BACKGROUND: This study was undertaken to identify the genes in response to areca nut extract, a potential carcinogen of oral cancer. METHODS: Two oral cancer sublines chronically treated with areca nut extract were established. Methods such as microarray and immunohistochemistry were used to screen and validate the genes' altered expressions in areca nut extract-sublines or in cancer tissues. RESULTS: A total of...

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PMID: 20848451
DOI: 10.1002/hed.21442

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