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Article

CD4 and CD8 T cell responses to the M. tuberculosis Ag85B-TB10.4 promoted by adjuvanted subunit, adenovector or heterologous prime boost vaccination.

PloS one - 1 Jan 2009

Elvang Tara, Christensen Jan P, Billeskov Rolf, Thi Kim Thanh Hoang Truc, Holst Peter, Thomsen Allan Randrup, Andersen Peter, Dietrich Jes

Abstract excerpt

BACKGROUND: Although CD4 T cells are crucial for defense against M.tb, it is still not clear whether the optimal response against M.tb in fact involves both CD4 and CD8 T cells. To test this, we used a new vaccine strategy that generated a strong balanced T cell response consisting of both CD4 an...

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Share to Adjuvants, Immunologic
Share to Antigens, Bacterial
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytotoxicity, Immunologic

Share to Immunization, Secondary

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Share to Vaccines, Subunit

Source

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Identifiers

PMID: 19357780
DOI: 10.1371/journal.pone.0005139
PMCID: PMC2663846

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19357780-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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