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Article

Genetic heterologous prime–boost vaccination strategies for improved systemic and mucosal immunity

1 Sept 2009

Abstract excerpt

In this article, we discuss the advantages and progress made with heterologous prime-boost vaccination strategies. Although the consecutive use of DNA and recombinant viral vectors induce greatly enhanced and sustained levels of both cell-mediated and humoral immunity in preclinical models, the results have not yet been translated to clinical use. Despite this, there is still a high level of optimism that these...

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PMID: 19722891
DOI: 10.1586/erv.09.86

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