Article
Phenotyping of cytochrome P450 3A enzyme in Gujarat population.
Drug metabolism letters - 1 Jan 2008
Jani Ashutosh J, Rathnam Shivprakash, Mehta Anita A
Abstract excerpt
CYP3A isoforms account for about 30% of total hepatic P450s. Most statins have been accepted probes for CYP3A4. The metabolic ratio of atorvastatin/ortho-hydroxyatorvastatin showed a bimodal distribution with respect to metabolism of atorvastatin. These observations showed that the frequency of occurrence of the poor metabolizer phenotype is 2.4 % in the Gujarat subjects.
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