Article
Pharmacogenomics of drugs affecting the cardiovascular system.
Clinical chemistry and laboratory medicine - 1 Apr 2003
Siest Gérard, Ferrari Luc, Accaoui Marie-José, Batt Anne-Marie, Visvikis Sophie
Abstract excerpt
The variability in drug response originates partly from genetics, with possible consequences for drug efficacy, adverse effects, and toxicity. Until now, pharmacogenetics mainly indicated the best known source of variability, that is, the variability caused by drug metabolism. However, simultaneous progress in the knowledge of biochemical targets of drugs and of the human genome, together with the development of...
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