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Article

ABCB1, SLCO1B1 and UGT1A1 gene polymorphisms are associated with toxicity in metastatic colorectal cancer patients treated with first-line irinotecan.

Drug metabolism letters - 1 Jan 2007

Rhodes Katrin E, Zhang Wu, Yang Dongyun, Press Oliver A, Gordon Michael, Vallböhmer Daniel, Schultheis Anne M, Lurje Georg, Ladner Robert D, Fazzone William, Iqbal Syma, Lenz Heinz-Josef

Abstract excerpt

We tested specific gene polymorphisms known to be involved in the irinotecan (CPT-11) metabolic pathway. The combination of at least one SLCO1B1 521 T allele, one ABCB1 1236 C allele and one UGT1A1*28 variant 7 repeat demonstrated a statistically significant association with Grade 3/4 toxicities...

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Source

Identifiers

PMID: 19356014
DOI: 10.2174/187231207779814328

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19356014-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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ABCB1, SLCO1B1 and UGT1A1 gene polymorphisms are associated with toxicity in metastatic colorectal cancer patients treated with first-line irinotecan.PMID 19356014Read ↗

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