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Article

Hypoxia and Temperature Regulated Morphogenesis in Candida albicans

14 Aug 2015

Abstract excerpt

Candida albicans is a common commensal in the human gut but in predisposed patients it can become an important human fungal pathogen. As a commensal, C. albicans adapts to low-oxygen conditions and represses its hyphal development by the transcription factor Efg1, which under normoxia activates filamentation. The repressive hypoxic but not the normoxic function of Efg1 required its unmodified N-terminus, was...

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PMID: 26274602
DOI: 10.1371/journal.pgen.1005447

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