Article
SCN5A mutation associated with acute myocardial infarction.
Legal medicine (Tokyo, Japan) - 1 Apr 2009
Oliva Antonio, Hu Dan, Viskin Sami, Carrier Tabitha, Cordeiro Jonathan M, Barajas-Martinez Hector, Wu Yusheng, Burashnikov Elena, Brugada Ramon, Rosso Rafael, Guerchicoff Alexandra, Pollevick Guido, Pascali Vincenzo L, Antzelevitch Charlie
Abstract excerpt
Ventricular tachycardia and fibrillation (VT/VF) complicating Brugada syndrome, a genetic disorder linked to SCN5A mutations, and VF complicating acute myocardial infarction (AMI) have both been linked to phase 2 reentry. Because of these mechanistic similarities in arrhythmogenesis, we examined the contribution of SCN5A mutations to VT/VF complicating AMI. Nineteen consecutive patients developing VF during AMI...
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