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Article

Gain-of-function mutation of the SCN5A gene causes exercise-induced polymorphic ventricular arrhythmias.

Circulation. Cardiovascular genetics - 1 Dec 2014

Swan Heikki, Amarouch Mohamed Yassine, Leinonen Jaakko, Marjamaa Annukka, Kucera Jan P, Laitinen-Forsblom Päivi J, Lahtinen Annukka M, Palotie Aarno, Kontula Kimmo, Toivonen Lauri, Abriel Hugues, Widen Elisabeth

Abstract excerpt

BACKGROUND: Over the past 15 years, a myriad of mutations in genes encoding cardiac ion channels and ion channel interacting proteins have been linked to a long list of inherited atrial and ventricular arrhythmias. The purpose of this study was to identify the genetic and functional determinants underlying exercise-induced polymorphic ventricular arrhythmia present in a large multigenerational family. METHODS AND...

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PMID: 25210054
DOI: 10.1161/CIRCGENETICS.114.000703

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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