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Article

Axonal mitochondrial clusters containing mutant SOD1 in transgenic models of ALS.

Antioxidants & redox signaling - 1 Jul 2009

Sotelo-Silveira Jose R, Lepanto Paola, Elizondo Victoria, Horjales Sofia, Palacios Florencia, Martinez-Palma Laura, Marin Monica, Beckman Joseph S, Barbeito Luis

Abstract excerpt

We studied the subcellular distribution of mitochondria and superoxide dismutase-1 (SOD1) in whole mounts of microdissected motor axons of rats expressing the ALS-linked SOD1-G93A mutation. The rationale was to determine whether physical interactions between the enzyme and mitochondria were linked to the axonopathy of motor fibers occurring in amyotrophic lateral sclerosis (ALS). Mitochondria and SOD1 displayed a...

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Identifiers

PMID: 19344250
DOI: 10.1089/ars.2009.2614
PMCID: PMC2842590

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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