Article
Functional polymorphisms of PTPN22 and FcgR genes in Tunisian patients with rheumatoid arthritis.
Archives de l'Institut Pasteur de Tunis - 1 Jan 2009
Sfar I, Dhaouadi T, Habibi I, Abdelmoula L, Makhlouf M, Ben Romdhane T, Jendoubi-Ayed S, Aouadi H, Ben Abdallah T, Ayed K, Zouari R, Lakhoua-Gorgi Y
Abstract excerpt
To investigate a possible association between functional polymorphisms of the protein tyrosine phosphatase nonreceptor type 22 (PTPN22-R620W) and receptors for the Fc fragment of IgG (FcgRIIa-H131R, FcgRIIIa-F158V FcgRIIIb-NA1/NA2), and rheumatoid arthritis (RA), 133 Tunisian patients with RA and 100 controls were genotyped. We found strong evidence of an association of PTPN22 620W allele and RA. However,...
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