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Article

Inhibition of monoamine oxidase by (E)-styrylisatin analogues.

Bioorganic & medicinal chemistry letters - 1 May 2009

Van der Walt Elizna M, Milczek Erika M, Malan Sarel F, Edmondson Dale E, Castagnoli Neal, Bergh Jacobus J, Petzer Jacobus P

Abstract excerpt

Previous studies have shown that (E)-8-(3-chlorostyryl)caffeine (CSC) is a specific reversible inhibitor of human monoamine oxidase B (MAO-B) and does not bind to human MAO-A. Since the small molecule isatin is a natural reversible inhibitor of both MAO-B and MAO-A, (E)-5-styrylisatin and (E)-6-styrylisatin analogues were synthesized in an attempt to identify inhibitors with enhanced potencies and specificities...

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Identifiers

PMID: 19342233
DOI: 10.1016/j.bmcl.2009.03.030
PMCID: PMC2693004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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