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Article

Inhibition of cholinesterases by safranin O: Integration of inhibition kinetics with molecular docking simulations.

Archives of biochemistry and biophysics - 15 Feb 2021

Onder Seda, Sari Suat, Tacal Ozden

Abstract excerpt

In the present study, the inhibitory mechanisms and effects of a synthetic phenazine dye, safranin O (SO) on human plasma butyrylcholinesterase (BChE), human erythrocyte acetylcholinesterase (AChE) and recombinant BChE mutants were investigated. Kinetic studies showed the following information: SO leaded to linear competitive inhibition of human plasma BChE with Ki = 0.44 ± 0.085 μM; α = ∞. It acted as a...

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Identifiers

PMID: 33345803
DOI: 10.1016/j.abb.2020.108728

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