The Importance of Understanding MHC-I Diversity in Nonhuman Primate Models of Human Infectious Diseases.

Abstract excerpt

Decades of research, including the 1996 Nobel Prize in Medicine, confirm the evolutionary and immunological importance of CD8 T lymphocytes (TCD8+) that target peptides bound by the highly variable major histocompatibility complex class I (MHC-I) proteins. However, their perceived importance has varied dramatically over the past decade. Regardless, there remains myriad reasons to consider the diversity of MHC-I...

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• Share to CD8-Positive T-Lymphocytes
• Share to Disease Models, Animal
• Share to Histocompatibility Antigens Class I