Article
Influence of genetic background on tumor karyotypes: evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology - 1 Jan 2009
Thomas Rachael, Wang Huixia J, Tsai Pei-Chien, Langford Cordelia F, Fosmire Susan P, Jubala Cristan M, Getzy David M, Cutter Gary R, Modiano Jaime F, Breen Matthew
Abstract excerpt
Recurrent chromosomal aberrations in solid tumors can reveal the genetic pathways involved in the evolution of a malignancy and in some cases predict biological behavior. However, the role of individual genetic backgrounds in shaping karyotypes of sporadic tumors is unknown. The genetic structure of purebred dog breeds, coupled with their susceptibility to spontaneous cancers, provides a robust model with which...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.