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Article

Canine population structure: assessment and impact of intra-breed stratification on SNP-based association studies.

PloS one - 19 Dec 2007

Quignon Pascale, Herbin Laetitia, Cadieu Edouard, Kirkness Ewen F, Hédan Benoit, Mosher Dana S, Galibert Francis, André Catherine, Ostrander Elaine A, Hitte Christophe

Abstract excerpt

BACKGROUND: In canine genetics, the impact of population structure on whole genome association studies is typically addressed by sampling approximately equal numbers of cases and controls from dogs of a single breed, usually from the same country or geographic area. However one way to increase the power of genetic studies is to sample individuals of the same breed but from different geographic areas, with the...

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PMID: 18091995
DOI: 10.1371/journal.pone.0001324
PMCID: PMC2129117

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